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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs  

LEUKEMIA

HOFERKOVA, E.; SEDA, V.; KADAKOVA, S.; VERNER, J.; LOJA, T.; MATULOVA, K.; FRANCOVA, HS.; ONDROUSKOVA, E.; FILIP, D.; BLAVET, N.; BOUDNY, M.; PAVLASOVA, GM.; VECERA, J.; ONDRISOVA, L.; PAVELKOVA, P.; HLAVAC, K.; KOSTALOVA, L.; MICHAELOU, A.; POSPISILOVA, S.; DORAZILOVA, J.; CHOCHOLA, V.; JAROS, J. ; DOUBEK, M.; JAROSOVA, M.; HAMPL, A.; VOJTOVA, L.; KREN, L. ; MAYER, J.; MRAZ, M, 2024: Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs. LEUKEMIA 38(8), p. 1699 - 13, doi: 10.1038/s41375-024-02284-w; FULL TEXT

Research Groups:

• Advanced Biomaterials
• Bioinformatics Core Facility
• Microenvironment of Immune Cells
• Genomics Core Facility

CEITEC authors:

• Lucy Vojtová, Ph.D.
• Jana Dorazilová
• Eva Hoferková
• Václav Šeda, Ph.D.
• Tomáš Loja, Ph.D.
• Daniel Filip
• Nicolas Blavet, Ph.D.
• Miroslav Boudný, Ph.D.
• Josef Večeřa, Ph.D.
• Laura Ondrišová
• Petra Pavelková
• Kryštof Hlaváč
• Lenka Košťálová
• Androniki Michaelou
• Prof. Marek Mráz, Ph.D.