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Separation approaches to enhance the selectivity of paper based microfluidic devices
Paperfluidics and paper-based analytical devices (µPADs) come to be very popular as ultimately portable and low-cost analytical platform. Arguably their weakest point is their often limited selectivity. Yet separation approaches have been implemented into µPADs to a limited degree. The speaker will first focus on elements critical to the success of µPADs. In the critical detection step, distance-based detection methods eliminate the need for any external detector/device and thus enable instrument-free assays. Then to implement a separation element in the µPADs, we explored the use of molecule imprinted polymer to modified µPADs with distance-based detection. We investigated this approach for analysis of proteins as markers in biological fluids such as urine, and of pesticides in environmental waters. Further we explored in‑situ formation of quantum dot nanoparticles to facilitate enzyme-based analysis using µPADs.