About event
It is well known that intrinsically disordered proteins proteins constitute about one third of our proteome and that they play important regulatory roles in many physiological processes. The talk will present examples of this very diverse group of proteins and discuss how their biological activities are encoded in their highly flexible structures. The examples will include proteins involved in brain development, in bacterial transcription, and in attack of host cells during meningitis infection. It will be explained how interactions and phosphorylations of disordered proteins can be studied with resolution of individual residues and how transient structural features directly and strongly influence regulatory functions. Following the mission of the PI seminars, the goal is to address audience outside the structural biology community and inspire possible collaborations.
