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About event
From a wider viewpoint, aldol-type reactions involve the addition of compounds with active hydrogen to molecules having a carbonyl or extended carbonyl functionality. Although chiral aldol units are appealing for creating bioactive structures, conducting these reactions enantioselectively and dealing with the downstream chemistry of enantioenriched aldol adducts are both far from straightforward. Many aldol products are susceptible to retro-aldol cleavage and elimination, leading to undesired epimerization or dehydration during isolation or the subsequent reaction sequences. Moreover, lower aliphatic aldehydes are either gases or low-boiling liquids, requiring special handling procedures.
These are just some of the challenges in achieving high enantioselectivity for aldol-type processes while developing and screening chiral bifunctional hydrogen bond donor organocatalysts in our group.
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This event is part of the Principal Investigator Seminar Series, the schedule of seminars can be found here.
