About event
The impact of technology on the life science and biomedical field has been truly remarkable. Whilst these innovations have direct health and economic benefits in the near and intermediate terms, current life science discovery and medical research development could be resource and carbon intensive, or undermining ethical practices, which are not sustainable in the long term. This presentation will illustrate my group’s research work on three themes (i) organ-on-a-chip, organoid, tumoroid bioassembly ref[1-6]; (ii) 3D printing of soft and biological materials ref[5-9]; and (iii) fibre biofabrication for wearable sensors and bioelectronics ref[10-12]. I will also discuss an outlook on how multiscale biofabrication can be harnessed to broaden the impacts of system ‘engineering biology’ - through creating more complex in vitro models, and to make sustainable e-textile or imperceptible bioelectronic interfaces for living systems.
References
1. Microfluidic on-chip biomimicry for 3D cell culture: a fit-for-purpose investigation from the end user standpoint, Liu et al. Future science OA (2017) 3 (2), FSO173
2. On-chip perivascular niche supporting stemness of patient-derived glioma cells in a serum-free, flowable culture Gerigk et al. Lab on Chip (2021), 21, 2343
3. Modeling Structural Elements and Functional Responses to Lymphatic-Delivered Cues in a Murine Lymph Node on a Chip Mazzaglia et al. Adv Health Mater (2024) adhm.202303720
4. Bio-assembling Macro-Scale, Lumenized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion. Liu et al. Advanced Science (2021), 8, 2003332.
5. Bioprinting of three-dimensional culture models and organ-on-a-chip systems. Huang et al. MRS Bulletin (2017) 42 (8), 593-599
6. Deployable extrusion bioprinting of compartmental tumoroids with cancer associated fibroblasts for immune cell interactions. Mazzaglia et al. Biofabrication (2023), 15, 025005
7. A hackable, multi-functional, and modular extrusion 3D printer for soft materials. Lei et al. Scientific Reports (2022), 12, 12294
8. Soft Hydrogel Shapeability via Supportive Bath Matching in Embedded 3D Printing. Lei et al. Advanced Materials Technology (2023), 8, 2300001.
9. 3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients. Lei et al. Nature Communications (2021), 12, 6260.
10. Inflight fiber printing toward array and 3D optoelectronic and sensing architectures. Wang et al. Science Advances (2020) 6. eaba0931.
11. Sustainable electronic textiles towards scalable commercialization. Shi & Huang et al. Nature Materials(2023), 22, 1294
12. Imperceptible augmentation of living structures with organic bioelectronic fibres. Wang et al. Nature Electronics(2024), doi:10.1038/s41928-024-01174-4
