3rd ML4NGP Training School "NMR for Intrinsically Disordered Proteins (IDPs)"

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About event

Course: NCBR003 NMR Data for Structural Bioinformatics

The course is intended for students of Masaryk University, and as part of the enrolled NCBR003_NMR Data for Structural Bioinformatics, the students will participate in the theoretical part of the ML4NGP Training School.

The aim of this Training School is to explore the origin of NMR data, the procedure of their analysis and interpretation, including potential sources of bias and error. Throughout almost one week, the participants will learn the principles and practicalities of NMR to better understand how data reflects Intrinsically Disordered Proteins (IDPs) behavior in near-native states. Discussions on NMR and other experimental techniques will provide unique insights on the limitations of NMR for IDP research, creating opportunities for advancing the field.

Programme

• Monday, 3 February

08:30–09:00 Registration
09:00–09:10 Welcome and introduction
09:10–09:50 Theory (D29/room 252): NMR introduction  |  Lukáš Žídek
09:50–10:15 Visit to NMR laboratory
10:15–10:40 Coffee break (C04/room 211)
10:40–12:20 Practical Session (C04/room 118): NMR software  |  Pavel Kadeřávek
12:20–13:30 Lunch (C04/room 211)
13:30–14:30 Theory (D29/room 252): Chemical Shifts  |  Michele Vendruscolo
14:30–15:30 Theory (D29/room 252): Diffusion-Ordered NMR Spectroscopy  |  Gyula Batta
15:30–16:00 Coffee break (C04/room 211)
16:00–17:00 Practical Session (C04/room 118): Chemical Shifts  |  Michele Vendruscolo
17:00–18:00 Practical Session (C04/room 118): Diffusion-Ordered NMR Spectroscopy  |  Gyula Batta
18:00 Dinner (C04/room 211)

• Tuesday, 4 February

08:30–10:00 Theory (D29/room 252): J couplings  |  Frans Mulder
10:00–10:30 Coffee break (C04/room 211)
10:30–12:30 Practical Session (C04/room 118): J couplings  |  Frans Mulder
12:30–13:40 Lunch (C04/room 211)
13:40–15:30 Theory (D29/room 252): NMR relaxation  |  Fabien Ferrage
15:30–16:00 Coffee break (C04/room 211)
16:00–18:00 Practical Session (C04/room 118): NMR relaxation  |  Fabien Ferrage
18:00 Dinner (C04/room 211)

• Wednesday, 5 February 

08:30–09:30 Theory (D29/room 252): Nuclear Overhauser Effect  |  Jiří Mareš
09:30–10:00 Coffee break (C04/room 211)
10:00–12:00 Practical Session (C04/room 118): Nuclear Overhauser Effect  |  Jiří Mareš
12:00–13:10 Lunch (C04/room 211)
13:10–14:40 Theory (D29/room 252): PRE, PRI, EPR, DNP  |  Dennis Kurzbach
14:40–15:10 Coffee break (C04/room 211)
15:10–17:10 Practical Session (C04/room 118): PRE, PRI, EPR, DNP  |  Dennis Kurzbach
18:00 Dinner (in the city centre)

• Thursday, 6 February 

08:30–10:10 Theory (D29/room 252): Interaction studies  |  Hugo van Ingen
10:10–10:40 Coffee break (C04/room 211)
10:40–12:40 Practical Session (C04/room 118): Interaction studies  |  Hugo van Ingen
12:40–13:50 Lunch (C04/room 211)
13:50–15:30 Theory (D29/room 252): DC and cross-relaxations  |  Marco Schiavina
15:30–16:00 Coffee break (C04/room 211)
16:00–18:00 Practical Session (C04/room 118): DC and cross-relaxations  |  Marco Schiavina
18:00 Dinner (C04/room 211)

• Friday, 7 February

08:30–09:45 Theory (D29/room 252): Post-translational modifications  |  Isabelle Landrieu
09:45–10:45 Theory (D29/room 252): In-cell NMR  |  Enrico Luchinat
10:45–11:15 Coffee break (C04/room 211)
11:15–12:15 Practical Session (C04/room 118): Post-translational modifications  |  Isabelle Landrieu
12:15–13:00 Practical Session (C04/room 118): In-cell NMR  |  Enrico Luchinat
13:00–14:10 Lunch (C04/room 211)
14:10–15:40 Theory (D29/room 252): IDPs ensembles  |  Martin Blackledge
15:45–16:15 Coffee Break (C04/room 211)
16:15–18:00 Practical Session (C04/room 118): IDPs ensembles  |  Martin Blackledge
18:00 Dinner (C04/room 211)