DIANA panel for testing of selectivity of inhibitors of clinically relevant protein kinases and its application in the drug discovery market. Preclinical development of new inhibitors of CDK11 - key enzyme for growth of cancer cells.
,
, 2021 - 2024
Signaling propensity in the microenvironment of B cell chronic lymphocytic leukemia
,
Evropská unie, 2019 - 2024
Characterization of kinase activity of cyclin-dependent kinase 11 (CDK11), an essential enzyme for the growth of cancer
,
Grantová agentura ČR, 2021 - 2023
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
,
Masarykova univerzita, 2019 - 2020
Creating synergies between research infrastructures to stimulate innovation in the cross-border region
(ATCZ40),
Ministerstvo pro místní rozvoj ČR, 2016 - 2020
Characterization of novel substrates and function for ovarian cancer-related cyclin-dependent kinase 12 (Cdk12)
(GA17-13692S),
Grantová agentura ČR, 2017 - 2019
Národní centrum lékařské genomiky
(LM2015091),
Ministerstvo školství, mládeže a tělovýchovy ČR, 2016 - 2019
Charakterization of a new factor in regulation of transcription/mRNA processing of histone genes
,
Masarykova univerzita, 2018 - 2019
NCLG - Národní centrum lékařské genomiky - modernizace infrastruktury a výzkum genetické variability populace
(CZ.02.1.01/0.0/0.0/16_013/0001634),
Ministerstvo školství, mládeže a tělovýchovy ČR, 2017 - 2019
Regulace genové exprese novým faktorem vázajícím mRNA
(GA16-10930S),
Grantová agentura ČR, 2016 - 2018
Genome-wide analyses of a “non-canonical” cyclin-dependent kinase (CDK)
(MUNI/E/0080/2017),
Masarykova univerzita, 2017 - 2017
Role Cdk12 a C-terminální domény RNA polymerázy II v transkripcně regulovaném procesu genomové nestability
(GA14-09979S),
Grantová agentura ČR, 2014 - 2016
Expression and function of activation-induced cytidine deaminase splice variants in normal B cell physiology and chronic lymphocytic leukemia
(3SGA5792),
Jihomoravský kraj, 2013 - 2016
Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem
(NT13547-4/2012),
Ministry of Health of the CR, 2012 - 2015
Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients
(NT/13549),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
Analysis of EGFR signalling and microRNA expression profiles in prediction of response to anti-EGFR
(NT/13860),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response
(NT11218),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2015
MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients
(NT/13514),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
Complex characterization of molecular genetic changes in glioblastoma multiforme and its relapses, and evaluation of their possible significance in oncologic therapy and therapy effect
(NT/13581),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
NGS-PTL - Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia
(306242),
Evropská unie, 2012 - 2015
Funkční charakterizace unikátních zásobních ribonukleoproteinových částic v pylu
(GAP501/11/1462),
Grantová agentura ČR, 2011 - 2014
Development of microRNA diagnostic panel for identification Barret esophagus patients at high-risk of progression to adenocarcinoma
(NT13585),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2014
SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny
(CZ.1.07/2.3.00/20.0045),
Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2014
The roles of Cdk12 in ovarian tumorigenesis
,
Ostatní - zahraniční, 2013 - 2014
The roles of Cdk12 in ovarian tumorigenesis
(MFR2013),
Foundations - International - Marsha Rivkin Center, 2013 - 2014
Real-time PCR soupravy pro diagnostiku v onkologii
(FR-TI2/254),
Ministerstvo průmyslu a obchodu ČR, 2010 - 2013
Nová izoforma cyklinu K je partnerem kinázy cdk12 regulující transkripci a alternativní sestřih u eukaryot
(GAP305/11/1564),
Grantová agentura ČR, 2011 - 2013
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
(MSM0021622430),
Ministerstvo školství, mládeže a tělovýchovy ČR, 2007 - 2013
Novel methylation of Hexim1 and cyclin composition of positive trancription elongation factor b (P-TEFb) regulate kinase activity of cdk9
(ME09047),
MEYS - KONTAKT, 2009 - 2013
Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma
(NT/11214),
Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2013
Regulace a funkce P-TEFb komplexů
,
Jihomoravský kraj, 2010 - 2013
Regulation and function of P-TEFb complexes
(SRGA 454),
South Moravian Region - SoMoPro, 2010 - 2013
Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoizomerases
(GAP301/10/0590),
Czech Science Foundation - Standard Grants, 2010 - 2012
Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development
(NS10439),
Ministry of Health - Departmental Programme of Research and Development (2008-2011), 2009 - 2011
